A shopping cart handle cover includes a generally elongated, flexible cover base panel; a generally elongated, flexible cover top panel carried by the cover base panel; and a cover interior defined by and between the cover base panel and the cover top panel. The shopping cart handle cover is designed to slide over a shopping cart handle. The handle cover can be fabricated of a material having elastic properties, allowing the user to stretch the handle cover over the cart handle. The handle cover becomes taut over the cart handle when in a relaxed state. At least one panel handle flap can be provided through the top and base panels. The flap wraps around the cart handle providing protection to the user from bacteria, other microorganisms, and other contaminants. A plurality of handle covers may be provided by joining adjacent covers, providing a perforation therebetween, and rolling the covers onto a core for dispensing.